Posted by Andrew.
Google Employee Shawn posted a guide in Google Discussions on Jan 15, 2009, there is a solution to fix the problem that can't reply to or compose new email when using Hotmail in Google Chrome.
You can test it out by downloading the developer build from here http://dev.chromium.org/getting-involved/dev-channel/ or you can wait until the next time your Google Chrome automatically updates. If you do choose to test out the developer build, please do following steps:
"C:/Documents and Settings/<username>/Local Settings/Application Data/Google/Chrome/Application/chrome.exe" --user-agent="Mozilla/5.0 (Windows; U; Windows NT 5.1; en-US) AppleWebKit/525.19 (KHTML, like Gecko) Version/3.1 Safari/525.1"
Yea, it is a really long string to add to your shortcut. Please note that this is only a temporary workaround and we're still working on a better solution. Stay tuned and I'll keep you guys updated.
The original guide post from Google Chrome Help Forum:
[Google Chrome Guide Post] Hotmail Fix
Good news for you all. :) We've submitted a patch that's a temporary workaround for issues with Hotmail as well as Yahoo mail. We're in discussion with Microsoft about the issue and while the Microsoft Hotmail team works on a proper fix, we're deploying this workaround that changes the user agent string that Google Chrome sends when requesting URLs that end with mail.live.com.
If you've been using the --user-agent switch to use Hotmail, you can remove the switch from your shortcuts with this release.
Everyone with the stable and beta version of Google Chrome will be eventually updated to version 22.214.171.124 or you can also update on demand by going to the Tools (wrench) menu, selecting 'About Google Chrome' and checking for updates.
I included a link to our blog post with more information about the update below.